WP THEMES PLUGINS WIDGETS

Hi
I have been using Wordpress for some time now and love the thumbnail gallery type plugins that are available.
It is possible to create something similar in a general non CMS website, not using Flash itself? I can do the basic type with JavaScript or html but I want to jazz it up a little.
Example of thumbnail:
http://www.scorpionbabyentertainment.com/
Scroll to the bottom.
Thanks you for your time.
Ash

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